Sarah Silverman

Herself

Nathan Barnatt

Homeless Man (segment "Lisa")

Lauren Lapkus

Girl 5 (segment "Lisa")

John C. Reilly

Father (segment "Ham")

Laura Silverman

Herself (segment "Knickers")

Seth Rogen

Officer Durand (segment "Knickers")

Jade Catta-Preta

Mother (segment "Lisa")

Natasha Leggero

Girl 2 (segment "Lisa")

Shelby Fero

Girl 1 (segment "Lisa")

Nathan Fielder

Himself (segment "Retro Video Arcade")

David Dineen-Porter

Himself (segment "Retro Video Arcade")

Kyle Dunnigan

Michael Daniel Cassady

Himself (segment "Lisa")

Brett Gelman

Himself

Emily Maya Mills

Girl 6 (segment "Lisa")

Nick Rutherford

Father (segment "Lisa")

Rob Schrab

Paul Rust

Himself (segment "Lisa")

Stoney Sharp

Armen Weitzman

Mailman

Kulap Vilaysack

Girl 3 (segment "Lisa")

Eric Wareheim

Harris Wittels

Scientist 1 (segment "CCDF")

Charlyne Yi

Tig Notaro

Girl 4 (segment "Lisa")

Todd Glass

Grace Helbig

Bride 5 (segment "Absorption")

2 Chainz

Himself (segment "Absorption")

Casey Ford Alexander

Bad Guy 2 (segment "CCDF")

Jack Bornoff

Tomato Man (segment "Ham")

Hailey Boyle

Cashier (segment "Knickers")

Aaron Chrenen

Cooper (segment "Ginger Orphan Playhouse") (voice)

Larry A. Davies

Lloyd (segment "Absorption")

Greg Davis Jr.

Groom 2 (segment "Absorption")

Donna DuBain

Madame Trinkett (segment "Ginger Orphan Playhouse") (voice)

Trevor Eyster

Bad Guy 1 (segment "CCDF")

Malinda Farrington

Malinda (segment "Ham")

Kate Freund

Prostitute (segment "CCDF")

David Garcia

Bad Guy 3 (segment "CCDF")

Cyrus Ghahremani

Himself

Hannah Hart

Bride 4 (segment "Absorption")

Deloris Heard

Customer (segment "Knickers")

Pamela Immel

Pamela (segment "Ham")

Zack Kennedy

Band Member 4 (segment "Absorption")

Keegan-Michael Key

Himself (segment "Absorption")

Ben Lepley

Vacuum Salesman (segment "Ginger Orphan Playhouse") (voice)

Catherine Lydon

Cashier (segment "Ham")

Rasika Mathur

Bride 3 (segment "Absorption")

Kyle Pacek

Son (segment "Ham")

Sandeep Parikh

Groom 3 (segment "Absorption")

Jordan Peele

Himself (segment "Absorption")

Issa Rae

Bride 2 (segment "Absorption")

Ron Ransen

Band Member 1 (segment "Absorption")

Mike Relm

Himself

Willy Roberts

Taco Truck Worker (segment "CCDF")

Chase Stewart

Son (segment "Lisa")

Mark Taormino

Band Member 2 (segment "Absorption")

Brittani Taylor

Bride 1 (segment "Absorption")

Aono Tetsuji

Bad Guy 4 (segment "CCDF")

James Trenton

James (segment "Ham")

Jack Vale

Groom 1 (segment "Absorption")